Jumping genes suspected in Alzheimer’s. Duke Today, Mar. 8, 2017. A string of failed drug trials for Alzheimer’s has researchers questioning the reigning approach to battling the disease, which focuses on preventing amyloid buildup in the brain. Duke scientists have identified a molecular mechanism that could help explain how neurons begin to falter even before amyloid clumps appear. The culprit, they say, may be “jumping genes” that lose their normal controls with age and start to disrupt the machinery that fuels brain cells. Picked up by STAT.