Tiny light-up barcodes identify molecules by their twinkling

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Tiny light-up barcodes identify molecules by their twinkling.
1,100 Words on Duke Research, April 12, 2019. An imaging technique developed at Duke University could make it possible to peer inside cells and watch dozens of different molecules at once — by labeling them with short strands of light-up DNA that blink on and off with their own unique rhythm. Though they’re all the same color, the technique makes it possible to distinguish as many as 56 types by their twinkling, more cheaply than traditional methods and without fading over time. Picked up by Engadget.

Infiltrating an ovary

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Infiltrating an ovary. 1,100 Words on Duke Research. April 2, 2019
What might look like a green gumdrop or strands of red tinsel is actually a dense network of nerves forming within a developing mouse ovary. 

Clues to resistance

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Clues to resistance1,100 Words on Duke Research. February 5, 2019In 2000, 23-year-old Gimble from Gombe National Park — made famous by Jane Goodall — became the first wild chimpanzee to test positive for simian immunodeficiency virus (SIV), the primate precursor to HIV. Now, he and hundreds of other wild chimpanzees across sub-Saharan Africa are helping researchers understand what makes some chimps more resistant to infection.

Fates intertwined

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Fates intertwined1,100 Words on Duke Research. January 9, 2019. To most people, life-forms like this orange lichen are little more than curious decorations on rocks and trees, often overlooked. But to one Duke biologist, they represent one of the world’s oldest quid pro quos: a symbiosis between two kingdoms whose evolutionary fates are tightly intertwined.

Bard or bot?

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Bard or bot? Duke Today, November 15, 2018. Could a computer write sonnets convincing enough to fool people into thinking they were written by human poets? These students created an algorithm to find out.

Home advantage

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Home advantage1,100 Words on Duke Research. November 7, 2018. These yellow monkeyflowers grow within a few feet of their wildflower cousins without spreading into each other’s turf.

Kooky, spooky Dukies

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Kooky, spooky Dukies. October 17, 2018. When a teenage girl brings a boy home for the first time, a simple dinner party can turn into a night from hell — especially when her family’s idea of hospitality is to visit their moat and show off their torture devices.

What Star Trek can teach us about genetics and evolution

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What Star Trek can teach us about genetics and evolution. Duke Today, Sept. 13, 2018. Why do Vulcans look so much like us? Could ‘mutations’ induced by breaking the “Warp 10” speed barrier rapidly transform a person into a bizarre man-salamander? And how well does the romance between the different alien races in the Star Trek universe match what scientists know about how one species splits into two, and what keeps them distinct? Duke biologist and die-hard Trek fan Mohamed Noor explores the answers to these and other questions in his new book, “Live Long and Evolve,” a fact-filled guide to some of the real-world scientific principles underlying Gene Roddenberry’s sci-fi franchise.

Waterproof roots

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Waterproof roots. 1,100 Words on Duke Research. September 10, 2018The glowing yellow rectangles in this Arabidopsis root mark a layer of tightly packed cells that form the root’s inner skin, controlling the flow of water and nutrients into the plant from the soil. In a new study, Duke PhD Colleen Drapek of the Benfey lab identified two interacting genes that can “reprogram” other types of root cells to produce similar waterproofing in outer regions of the Arabidopsis root where they are not normally found. The findings could help researchers understand how such protective barriers in developing plant roots come to be, and eventually improve crop productivity in drought-prone or nutrient-poor soils.

Deadly molecules in motion

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Deadly molecules in motion. 1,100 Words on Duke Research, August 22, 2018. To some, this may look like a disco ball. But to one research team, it represents the elusive dance of a shape-shifting protein, SpA , which helps the bacterium Staphylococcus aureus evade its host’s defenses.